![]() Propofol can accumulate in the follicular fluid and even brief exposure led to deleterious effects on subsequent cleavage events of mouse oocytes 4. Despite its favorable pharmacokinetic properties and safety profile, animal studies have shown that it can affect early embryonic development 4, 5, 6. Intravenous propofol, with short induction and recovery times, is the drug of choice for oocyte retrieval performed under sedation. Significant decreases in hemoglobin concentration and plasma cortisol level, and increased blood glucose were observed 30 min after anesthesia induction 3. Consequently, perfusion to the follicles and the endometrium is decreased. Significant decreases in blood pressure have been reported 2 min after induction of anesthesia 2. General anesthesia may affect IVF outcomes indirectly through systemic hemodynamic and biochemical changes and directly through its effects on oocytes. Therefore, it is usually performed under anesthesia 1. Although minimally invasive, the procedure is painful. Oocyte retrieval is an important component of the in vitro fertilization (IVF) cycle. This impact on the developmental potential of oocytes may lead to negative IVF outcomes and should be investigated further. General anesthesia administered during oocyte retrieval may have adverse effects on the fertilization potential of oocytes. The differences in pregnancy and live birth rates between the groups were not statistically significant. ![]() There was no significant difference in the ratio of expected to retrieved oocytes between retrievals with and without anesthesia (0.8 ± 0.4 vs. Fertilization rate was lower in retrievals under anesthesia compared to without (53.4% ± 34.8 vs. ![]() A secondary outcome was the efficiency of follicle retrieval associated with the use of anesthesia. The primary outcomes were fertilization, pregnancy and live birth rates. Data were adjusted for age, BMI, estradiol on triggering day and total gonadotropin dose. ![]() IVF outcomes of 129 women who underwent oocyte retrieval under propofol anesthesia and 116 without anesthesia were compared. A total of 245 women undergoing IVF cycles were included in this retrospective cohort study. This study investigated whether administration of general anesthesia (specifically propofol) during oocyte retrieval affects IVF outcomes. Its effects on the outcomes of IVF cycles are uncertain. It does not store any personal data.General anesthesia is frequently administered during oocyte retrieval. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category. This cookie is used to enable payment on the website without storing any patment information on a server. This cookie is set by Stripe payment gateway. These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly.
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